Anthony Fauci is a fucking quack who should have been fired when he lied about AIDS transmission and failed to develop a vaccine for HIV — which was his fucking mandate back in the late 1980s when he took the job he still holds to this day.
But let’s talk about one of his biggest lies that probably killed thousands of people during our most recent SARS episode — that Hydroxychlorquine had no affect on SARS-CoV-2 infections and anyone who said so was a fucking liar.
Look in the mirror much, Tony? You fucking incompetent asshole. Because THIS ARTICLE WAS ON THE NIH WEBSITE ALL ALONG.
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.
Keywords: severe acute respiratory syndrome coronavirus, chloroquine, inhibition, therapy